We faced one of the issue, after successfull cloning of APPS R12.1.1, when we tried to open the form, it was not launching.
We did the following steps, and form started coming up.
1- Stopped the APPS Tier services.
2- rename the directory "tldcache" under following directories.
3- create the emplty directory with the name "tldcache" under the above directories.
4- restart the APPS Tier services.
5- test the issue.